#validation of uplc

[aralresearch]

Looking for purity by HPLC/UPLC services in Ahmedabad?

Chiral HPLC Testing Labs in Ahmedabad - Aral Research is the leading laboratory that offers HPLC/UPLC services in Ahmedabad at affordable prices. We have a highly experienced team that is well-equipped to develop the HPLC method for chiral and achiral molecules. Contact today!

[sudheervanguri]

ALS Testing Services India Private Limited  Recruitment Notification About ALS Global & Job Descriptions We Are Hiring Passionate Professionals in Life Sciences ALS Global is expanding into Biologics and Complex Generics Analytical Testing Services with our new brownfield project in Hyderabad. We have multiple openings for experienced professionals ready to make an impact in the life sciences industry. About ALS Global: ALS Global is a leading provider of testing, inspection, certification, and verification services, offering a wide range of solutions across industries, including life sciences, environmental, food, pharmaceutical, and more. With over 350 laboratories in more than 65 countries, ALS delivers tailored, scientifically sound, and reliable testing services, meeting the highest quality standards. We are expanding our life sciences division to include comprehensive analytical support for biologics and complex generics at our new Hyderabad facility. To learn more about ALS, visit www.alsglobal.com. Now Hiring for Hyderabad Brownfield Project: ALS Global is extending its services to provide tailored, scientifically sound, and reliable solutions in the life sciences domain, specifically for Biologics and Complex Generics Analytical Testing Services. We are seeking passionate candidates for our new brownfield project at Hyderabad. We have multiple openings across various levels, including: Tech Leads Team Leads Research Scientists Research Associates Executives Sr. Executives Domains & Key Areas of Expertise: 1. Analytical Characterization and Testing of Therapeutic Peptides, Proteins, and Oligos Qualifications: PhD / M.Tech / Pharm / MSc Experience: 3-8 years Key Responsibilities: Perform analytical characterization of therapeutic peptides (synthetic and recombinant), proteins, and oligonucleotides. Characterize primary structure, higher-order structures, product variants, and related impurities using various analytical techniques. Develop and validate methods using a Quality by Design (QBD) approach. Hands-on Experience with: Mass Spectrometry Methods: LCMS, HRMS, MALDI. Chromatographic Methods: HPLC/UPLC (Reverse Phase, Size Exclusion, Ion Exchange, Ion Chromatography), Peptide Mapping, Glycan Analysis. Spectroscopic Methods: Circular Dichroism (CD), UV-Vis, FT IR, Fluorescence. Electrophoresis Techniques: Gel electrophoresis, Capillary Electrophoresis (CE), CE SDS, Capillary Isoelectric Focusing (CIEF). Other Techniques: Sedimentation Velocity Analytical Ultracentrifugation (SV-AUC), Differential Scanning Calorimetry (DSC), Amino Acid Analysis (AAA). Ensure compliance with regulatory requirements and contribute to protocol and report preparation. 2. Cell-Based, Cell-Free Based, and Immunogenicity Testing Qualifications: PhD / M.Tech / MSc / B.Tech Experience: 3-8 years Key Responsibilities: Hands-on experience with mammalian cell culture and maintenance techniques, including cell-based bioassays, fluorescence assays, and immunoassays. Develop and validate cell-based bioassays for therapeutic peptides, proteins, and oligos. Experience in the development and validation of ELISA-based methods. Handle Peripheral Blood Mononuclear Cells (PBMCs) and perform immunogenicity-based testing. Operate equipment such as multimode readers and flow cytometers. Conduct qualification and commissioning of analytical equipment. Ensure knowledge of 21 CFR compliance, with a preference for experience in Contract Research Organizations (CROs). Prepare protocols, validation reports, and comply with regulatory guidelines. 3. Microbiology Testing Qualifications: PhD / M.Tech / MSc / B.Tech Experience: 3-8 years Key Responsibilities: Conduct Bacterial Endotoxin Testing (BET) on water, raw materials, and in-process samples. Develop and validate antimicrobial effectiveness testing. Perform microbiological assay batch release testing, including microbial limit testing, bioburden analysis, and sterility testing using isolator technology.

Conduct growth promotion tests and in vitro kill rate studies. Perform qualification and commissioning of microbiological analytical equipment. Ensure compliance with 21 CFR and other regulatory requirements, with a preference for those with experience in CROs. Prepare protocols and reports for validation and analysis. Open Positions: Tech Leads / Team Leads: Lead teams in method development, characterization, and validation of biologics and complex generics. Research Scientists / Research Associates: Conduct hands-on analytical testing, develop and validate methods, and ensure regulatory compliance. Executive / Sr. Executive Roles: Provide technical support for analytical and microbiological testing, method validation, and compliance activities. [caption id="attachment_106615" align="aligncenter" width="930"] ALS India career Recruitment - Job vacancies[/caption] ALS Global is committed to providing a supportive work environment, encouraging innovation, and fostering continuous improvement to provide high-quality testing and inspection services. If you are passionate about driving advancements in life sciences, we would love to hear from you! How to Apply You can submit your application by  clicking the link below, or emailing your CV directly to alsin.career@alsglobal.com. or Application Link

[dearmeleddy]

Quick update:-

Tuesday (10/9/2024) - preparation of calibration curve & qc & reconstitute sample till transfer into vial & injection inside the uplc system vitamin d.

Wednesday (11/9/2024) - understanding, reading & analysing the peak, data in Excel with formulated table provided (retention time, area, height, graph) result from the injection of qc, cc, samples. Visited the mycero lab at hukm, level 12, for uhplc for vitamin A & E.

Thursday - should be on method validation of uplc (not yet known)

[leedsomics]

Identification of urinary biomarkers of food intake for onion by untargeted LC-MS metabolomics. (arXiv:2311.17194v1 [q-bio.BM])

Scope: Biomarkers of food intake (BFIs) are useful tools for objective assessment of food intake and compliance. The aim of this study was to discover and identify urinary BFIs for onion. Methods and results: In a randomized controlled cross-over trial, 6 overweight participants (age 24-62 years) consumed meals with 20 g/d onion powder or no onion for 2 weeks. Untargeted UPLC-qTOF-MS metabolic profiling analysis was performed on urine samples and the profiles were analysed by multilevel-PLSDA, modified PLS, and nearest shrunken centroid to select features associated with onion intake. Eight biomarkers were tentatively identified; six of them originated from S-substituted cysteine derivatives such as isoalliin and propiin, which are considered the most specific for onion intake. Most of the biomarkers were completely excreted within 24 hours and no accumulation was observed during 2 weeks indicating their ability to reflect only recent intake of onions. Receiver-operator curves were made to evaluate the performance of individual biomarkers for predicting onion intake. The area under the curve values for these biomarkers ranged from 0.81 to 1. Conclusion: Promising biomarkers of recent onion intake have been identified in human urine. Further studies with complex diets are needed to validate the robustness of these biomarkers. http://dlvr.it/SzWcsj

[klaboratory-blog]

K Analytical Laboratory is a Pharmaceutical Research Centre & Training Institute. Certified With ISO 9001:2015, Which Provide Service in the Area of Research and Hands-On Training for latest Analytical instrument (HPLC, GC, GC-HS, GC-MS, UPLC, FT-IR, UV-VIS SPECTROPHOTOMETER) & other many more, also Provide Pharmaceutical Production Training (PILL , TABLET ,CAPSULE , SYRUP), Analytical Research Work , Project work for student, all Training Courses base on GMP,GLP, and Relented to PHARMACOPEIA, Practically, Theoretical, Calculation & Hands on training.

Guidance and technical facilities to Research, in Pharmaceutical, Food, Water, Cosmetic, Chemical, Analytical Support Service to industry, Analytical Method Development, Validation, Analytical testing.

Our highly educated and well experienced team, Analytical lab technician, Laboratory safety, & trouble shooting experts along with advanced technologies and modern Analytical instrument.

[symposiumgo]

Medical coding principally translates healthcare record, diagnosis, reports, medical services and systems into specific alphanumeric codes. It is centrally the process of translating extensive medical data and services into efficient and uncomplicated code. Follow the link and check out the full blog to read more.

[biotechtimes]

Sun Pharma Recruitment 2020: MSc Biochem & Biotech R&D Jobs

New Post has been published on https://biotechtimes.org/2020/07/15/sun-pharma-recruitment-2020-msc-biochem-msc-biotech-rd-jobs/

Sun Pharma Recruitment 2020: MSc Biochem & Biotech R&D Jobs

Sun Pharma Recruitment 2020

Sun Pharma Recruitment 2020 – MSc Biochem & Biotech R&D Jobs. Sun Pharmaceutical Inds Limited, Baroda is inviting biotech and biochem candidates for R&D Biotechnology Jobs. Sun Pharma will conduct virtual interviews for Biotech R&D Jobs. Interested candidates may check out this wonderful opportunity below:

Sun Pharma R&D Biotechnology Jobs

Virtual Walk-In interview on 19th July 2020 | Time: 1.00 pm – 6.00 pm

Mode of interview: Video / Telecon

Sun Pharma invites applications for virtual interviews to be held on 19th July 2020 for the below-mentioned positions. Please send in your resumes on email: Rosemary.varghese@sunpharma.com. The details of the call/link will be shared on 19th July 2020 to the candidates. The interviews will be conducted basis the selection of profiles suiting the requirements.

Downstream Processing Job

A) Positions Vacant: Executive / Sr Executive / Mgr – R&D Biotechnology (Downstream Processing)

Experience Required: 3 – 9 years

Qualification: M.Sc / M.Tech / MS Pharm in Biotechnology / Biochemistry

Job Description:

Well versed with Downstream Process and development purification by different methodologies.

Good knowledge of Operation of Akta systems and TFF- tangential flow filtration system for purification

Strong experience working with biologics products

Handling and usage of different types of resins, filters and cassette.

Experience in GMP documentation for manufacturing of purification process for recombinant antibody manufacturing will have added advantage.

Planning and management of resources related to DSP equipment’s spares, maintenance, consumables, and other inventory.

Ability to work towards deadlines and adhere to time schedules.

Ability to work effectively to solve problems in a multidisciplinary team environment.

Upstream Processing Job

B) Positions Vacant: Executive / Sr Executive / Manager – R&D Biotechnology (Upstream Processing)

Experience: 3 – 10 years

Qualification: M.Sc / M.Tech / MS Pharm in Biotechnology / Biochemistry

Job Description:

Hands-on experience in Mammalian cell culture, Shake flask studies, Microbial fermentation, process development, Process scale down, Process characterization and technology transfer.

Experience in experimental execution, Data analysis, Troubleshooting for Upstream Process development for biotherapeutics.

Sound knowledge of cGMP, Global Regulatory submissions, DOE and QBD implementation

Ability to work as a team member in a highly demanding scientific work culture.

Protein Characterization Job

C) Positions Vacant: Executive / Sr Executive / Manager- R&D Biotechnology (Protein Characterization)

Experience: 2 – 9 years

Qualification: M.Sc / M.Tech / Ph.D. in Biotechnology / Biochemistry

Job Description:

Analytical method development for recombinant proteins characterization.

Validating test methods used in product characterization & bio-similarity assessment.

Independently design and perform analysis, including but not limited to, HPLC/UPLC, CE, Mass Spectrometry, ELISA, cell-based assay and others. Interpret results and write report with sound rational.

Development of quality target profile (QTP) using reference drug sourced from US, EU & IND.

Writing/reviewing of SOPs, STP, qualification protocol & qualification report.

Preparing quality dossier for regulatory submission.

Routine IPQC sample analysis and report preparation.

Analytical Method transfer to the production unit

View Notification

[sudheervanguri]

Opportunity at Teadus Pharma for Analytical R&D Professionals in Hyderabad Introduction Teadus Pharma invites talented professionals to join our team in Hyderabad for exciting opportunities in Analytical Research & Development (R&D). seeking individuals with expertise in handling HPLC and UPLC, method validation, calibration, and a strong understanding of compliance environments. Responsibilities Expertise in handling HPLC and UPLC with a variety of detectors, preferably including UV, PDA and RL Hand-on exposure to perform the method validation and method transfer as per current regulatory guidelines/requirements. Experience in writing clear and precise analytical validation protocols. Sound knowledge of calibration to perform and review of calibrations of Laboratory instruments as per schedule. Excellent review, problem-solving, organizational, and communication skills. Having the experience to prepare and review of Analytical Method Validation / Method Verification / Method Transfer Protocols and Reports. Having good understanding of compliance environment and experience of Good Laboratory Practices and Good Documentation Practices. Qualifications MSc in analytical chemistry or related field Minimum 5 years of experience in analytical method validation, preferably from the CRO/API Industry Location Join us at Teadus Pharma in Hyderabad and contribute to science for better health. How to Apply Submit your CV to hr@teaduspharma.com or contact 9100051070 for more information. [caption id="attachment_75524" align="aligncenter" width="930"] teadus pharma Recruitment - Job vacancies[/caption]

[jppres]

Development and validation of UPLC-UV method for the determination of rubraxanthone in human plasma

Development and validation of UPLC-UV method for the determination of rubraxanthone in human plasma. @JPPRes

Article published in Journal of Pharmacy & Pharmacognosy Research 7(5): 381-388, 2019. Meri Susanti1,2, Yahdiana Harahap2, Afrizal Itam3, Dachriyanus1*

1Faculty of Pharmacy, Andalas University, Padang, West Sumatra, 25163, Indonesia.2Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia.3Department of Chemistry, FMIPA, Andalas University, Padang, West Sumatra, 25163,…

[healthtimetaylor]

Eleutherococcus senticosus leaves can play a therapeutic role in treating ischemic stroke through different pathways.

PMID:  J Ethnopharmacol. 2019 Sep 15 ;241:111969. Epub 2019 May 22. PMID: 31125596 Abstract Title:  Mass spectrometry-based urinary metabolomics for the investigation on the mechanism of action of Eleutherococcus senticosus (Rupr.&Maxim.) Maxim. leaves against ischemic stroke in rats. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: As a traditional Chinese medicine, Eleutherococcus senticosus (Rupr.&Maxim.) Maxim. leaves (ESL) can treat ischemic, neurasthenia, and hypertension diseases. However, only few studies have been conducted on the mechanism of action of ESL for ischemic disease treatment.AIM OF THE STUDY: This study aimed to discover the potential biomarkers in the rats caused by ischemic stroke and build a gene-enzyme-biomarker network to explore the mechanism of ESL treatment on ischemic stroke further.MATERIALS AND METHODS: The urinary metabolomics strategy was developed by combining UPLC-Q-TOF/MS with multivariate data analysis. The gene-enzyme-biomarker network was built by Cytoscape 3.6.0 on the basis of the potential biomarkers filtered out via urinary metabolomic analysis. Then, the potential target enzymes of ESL in the treatment of ischemic stroke were selected for further validation analysis via the ELISA kits.RESULTS: A total of 42 biomarkers associated with ischemic stroke have been identified, among which 38 species can be adjusted by ESL, including 5'-methylthioadenosine, prostaglandin A2, l-methionine, aldosterone, 11b-hydroxyprogesterone, prostaglandin E3, dehydroepiandrosterone, taurine, 5-methoxyindoleacetate, and p-cresol glucuronide. These biomarkers were involved in several metabolic pathways, including taurine and hypotaurine, arachidonic acid, cysteine and methionine, steroid hormone biosynthesis, tryptophan, and tyrosine metabolism pathways. The gene-enzyme-biomarker network was built, and three predicted target proteins, including cyclooxygenase-2 (COX-2), monoamine oxidase (MAO), and nitric oxide synthase (NOS), were selected as the potential target enzymes for ESL in ischemic stroke treatment.CONCLUSIONS: All results showed that ESL can play a therapeutic role in treating ischemic stroke through different pathways. This study will provide an overall view of the mechanism underlying the action of ESL against ischemic stroke.

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[americajobsnet]

[Full-time] Chromatography & Spectrometry Wet Chemistry Laboratory Technician - Torrance, CA at Jobisite

Location: California URL: www.jobisite.com Description: Travel from site to site in localized territory as a wet chemistry customer support technician for an analytical lab equipment distributor. Requires extensive wet lab equipment experience as lab technician, chemist, or research associate. Train lab techs to setup and use instruments such as Gas Chromatographs, Liquid Chromatographs, Mass Spectrometers, Ultraviolet-visible Spectrometers, and similar. Perform installation of systems at customer sites. Train customers on instrument operation. Conduct preventative maintenance. Test, troubleshoot, and repair equipment. Calibrate and validate. Provide telephone support to customers. Join a company offering an industry competitive, uncapped income potential with full medical benefits, 401(k) retirement plan, excellent vacation policies, cutting edge product portfolio, and various professional development opportunities. Company also provides cell phone, laptop, credit card for meal expenses, and vehicle with allowance for personal use. For complete details contact James Franco at: (609) 584-9000 ext 283 Or, submit resume online at: dmc9.com/jef/app.asp Or email to: 1000038630_10007335 AT jobbank301.com Please reference #37619678 when responding. Education Requirements: Some College Minimum Experience Requirements: 2-5 years Job City Location: Torrance Job State Location: CA Job Country Location: USA Salary Range: $70,000to $110,000 Diedre Moire Corporation, Inc. Diedremoire_dot_com WE ARE AN EQUAL OPPORTUNITY EMPLOYER and our employment decisions are made without regard to race, color, religion, age, sex, national origin, handicap, disability or marital status. We reasonably accommodate individuals with handicaps, disabilities and bona fide religious beliefs. Jobs Career Position Hiring. CONSIDERED EXPERIENCE INCLUDES: Lab Tech Laboratory Technician Analytical Chemist Research Associate Wet Chemistry Lab Analytical Chemistry Lab Analytical Instrumentation Chromatography Liquid Chromatography Mass Spectrometry Gas Chromatography High Performance Liquid Chromatography Ultraviolet-visible Spectroscopy LC GC LCMS GCMS HPLC UPLC UV-Vis MS #DiedreMoire #LabTechJobs #WetChemistry #FieldService #JobSearch #JobHunt #JobOpening #Hiring #Job #Jobs #Careers #Employment #jobposting DISCLAIMER: We will make every effort to consider applications for all available positions and shall use one or more of the contact methods and addresses indicated in resume or online application. Indicated location may be proximate or may be desirable point of embarkation for paid or unpaid relocation to another venue. Job descriptions may fit single or multiple presently available or anticipated positions and are NOT an offer of employment or contract implied or otherwise. Described compensation is not definite nor precise and may be estimated and approximate and is negotiable depending on market conditions and candidate availability and other factors and is solely at the discretion of employers. Linguistics used herein may use First Person Singular and First Person Plural grammatical person construction for and with the meaning of Third Person Singular and Third Person Plural references. We reserves the right to amend and change responsibilities to meet business and organizational needs as necessary. Response to a specific posting or advertisement may result in consideration for other opportunities and not necessarily the incentive or basis of the response. Nothing herein is or may be considered a promise, guarantee, offer, pledge, agreement, contract, or oath. If you submit an application or resume which contains your email address, we will use that email address to communicate with you about this and other positions. We use an email quality control service to maintain security and a remove and dead address filter. To cancel receiving email communications, simply send an email from your address with the word "remove" in the subject line to pleaseremove_AT_candseek4.com Or, visit the website at jobbankremove_dot_com. If you have further concern regarding email received from us, call (609) 584-5499. Reference : Chromatography & Spectrometry Wet Chemistry Laboratory Technician - Torrance, CA jobs Apply to this job from America Jobs http://www.america-jobs.net/job/29635/chromatography-spectrometry-wet-chemistry-laboratory-technician-torrance-ca-at-jobisite/

[cancersfakianakis1]

Cyclophosphamide dose adjustment based on body weight and albuminemia in elderly patients treated with R-mini-CHOP

Abstract

Background

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in elderly patients, and R-CHOP chemotherapy is the standard treatment protocol for DLBCL. Elderly patients (often defined as 75 years of age) are treated with anticancer drugs with precaution; however, the pharmacokinetics and pharmacodynamics (PK and PD) of these agents have not been thoroughly investigated in this population. In this study, we investigated the PK of cyclophosphamide (CP) and doxorubicin (DOXO) in elderly patients in order to verify if there is an influence of age on the PK of these anticancer drugs.

Materials and methods

This is a prospective multi-center clinical trial investigating the PK of CP and DOXO in elderly and very elderly patients with DLBCL treated by R-mini-CHOP regimen. Dose levels were 25 mg/m2, 0.7–1.4 mg/m2, 750 mg/m2, and 375 mg/m2 for DOXO, Vincristine (VCR), CP, and Rituximab, respectively. For PK analysis, 7 time point samples were collected over 48 h post-administration on cycle 3. CP and VCR plasma concentrations were measured using UPLC–MS/MS validated method. DOX plasma concentrations were measured using UPLC coupled with fluorescence detection-validated method. PK-POP modeling has been performed with a non-linear mixed-effect model program (Monolix).

Results

31 patients (15 males and 16 females), 75 to 96 years old, were treated with R-miniCHOP protocol. Among them, 19 patients were treated with VCR. A one-compartment (1cpt) open model with linear elimination adequately described CP concentration–time courses. The population PK parameters for CP were: CL = 3.58 L/h, Vmale = 32.2 L, and Vfemale = 28.7 L. Body weight (BW), albuminemia, and gender demonstrated a significant impact on CP PK. A 2-compartment (2cpt) open model with linear elimination best described DOXO concentration–time courses. The population PK parameters for DOXO obtained for the structural model were: CL = 51.1 L/h, Q = 49.6 L/h, V1 = 29.4 L, V2 = 1,130 L (clearances: CL, Q, volumes of distribution: V1, V2). The main covariate effects on DOXO PK were related to gender, BW, and VCR administration. VCR increases DOXO V1 from 29.4 L to 57.5 L (p = 0.02). No hematologic and cardiac grade 3 or 4 toxicity were recorded.

Conclusions

Usually, in the absence of specific data, the majority of the physicians empirically reduce anticancer drug dose in the elderly patients (Tourani in J Geriatr Oncol 3(1): 41–48, 2012), or even does not treat these very-old patients. A better knowledge of the pharmacokinetics in very-old patients should allow a better dose adjustment based on the most significant physiological factors that modify the pharmacokinetic parameters. In this study, no serious toxicity was observed in these very elderly patients (84.1 years). This indicates that dose adjustment of chemotherapies should not only be based on age and creatinine clearance, but also, based upon appropriate physiological and biological data. Our findings indicate that, CP dose adjustment should be done according to serum albumin levels and patients BW and gender.

http://bit.ly/2DGctEh

[jobisitejobs]

Analytical Bench Chemist - Iowa City, IA

Ad Id: 1126932 Posted by The Veritas Healthcare Solutions, LLC in Iowa City Client Name : Cambrex Pharmaceuticals, IA Location : Iowa PROJECT: Client is expanding their R&D operation and needs additional chemist support.   Perform a wide variety of analytical chemical analyses for release of raw materials, intermediates and small molecule API drug substance with a proven ability in general wet chemistry and chromatography (HPLC, UPLC, GC) Perform instrument maintenance and troubleshoot equipment as needed Perform method development including instrument parameters, new instruments and method improvement studies Adhere to all EPA, FDA, cGMP and DEA regulations and internal SOPs as they relate to the operation of the Quality Control lab and general operation of the chemical production facility. Responsible for coverage of all job duties typical for analytical method development and validation Experience with Wet Chemistry, Chromatography (HPLC, UPLC, GC) -MUST, cGMP Regulation knowledge Experience in small molecule environment, Extensive knowledge of analytical instrumentation The ability to perform as an Analytical Bench Chemist (please highlight this experience thoroughly)   Healthcare / Pharma / Bio-tech  |  Jobs in Iowa City, IA Skills: Analytical AnalyticalBenchChemist-IowaCity,IA from Job Portal https://www.jobisite.com/extrJobView.htm?id=141188

[healthtimetaylor]

Comparative study of crude and wine-processing Corni Fructus on chemical composition and antidiabetic effects.

PMID:  Evid Based Complement Alternat Med. 2019 ;2019:3986964. Epub 2019 Dec 2. PMID: 31885645 Abstract Title:  Comparative Study of Crude and Wine-Processingon Chemical Composition and Antidiabetic Effects. Abstract:  Wine processing is a specialized technology which involves sautéing crude herbal medicine using Chinese rice wine. Herein, we identified the changes in chemical profiles and antidiabetic effects of(CF) after wine processing in high-fat diet (HFD) streptozotocin- (STZ-) induced diabetic mice. A novel high-efficiency method for simultaneously quantifying gallic acid, 5-hydroxymethylfurfural, morroniside, loganin, sweroside, and cornuside by UPLC was developed, and validating crude and wine-processing CF was done for the first time. Mice were randomly divided into the following groups and orally given different solutions for 4 weeks: normal group (NC, 0.4% (w/v) CMC-Na), model group (DM, 0.4% (w/v) CMC-Na), crude CF group (CP, 3.87 g/kg), and wine-processing CF group (PP, 3.87 g/kg) followed by HFD and multiple subcutaneous injection of STZ (40 mg/kg) to induce the diabetes model except the NC group. Biochemical indexes (body weight, fasting blood glucose level, lipid level, insulin, and free fatty acid) and other parameters involving liver toxicity were measured with commercial kits and immunohistochemical method. Comparative studies on pharmacology showed that the crude extracts possess higher efficacy on hypoglycemia and hypolipidemia, while wine-processing products exhibit better effects on liver preservation.Our data suggested that wine processing was recommended when CF was used for protecting the liver; however, crude products should be used as antidiabetic drugs.

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[markengine-blog]

Global Metabolomics Market Industry Analysis,Trends, and Forecast 2014 - 2024

Metabolomics is an omics sciences in systems biology and involves global valuation and validation of endogenous metabolites inside a biological system. With the technological advances in molecular biology, there has been significant development in the field of metabolomics. The developments analytical equipment and software have backed the development of metabolomics field. Similarly, increasing metabolomics research funding and government initiatives is a major driver for the growth of this market. Metabolomics science is used widely in biomarker discovery and drug assessment. Thus, the rapid development experienced by pharmaceutical and biotechnology sectors is supporting the growth of the metabolomics market. However, the dearth of skilled professionals in metabolomics science is expected to hamper the growth of the metabolomics market. Moreover, low adoption of advanced metabolomics products is the other factor deterring the growth of the metabolomics market.

Request Sample Report : http://www.mrrse.com/sample/1731

Metabolomics is gaining importance as a tool in the life sciences since it is a relatively fast and precise technique that can be applied with either a particular focus or in an overall manner to gain new knowledge about biological systems. This research study analyzes the market for metabolomics in terms of revenue (US$ Mn). For the research, 2015 has been considered as the base year, while all forecasts have been provided from 2016 to 2024. The global metabolomics market is segmented into three segments as technique, applications, and geography. The market by technique is further divided as separation techniques and detection techniques. Separation techniques includes study of gas chromatography, capillary electrophoresis, high performance liquid chromatography (HPLC) and ultra-performance liquid chromatography (UPLC). The HPLC accounted for the highest share of metabolomics market by technique. Detection technique includes nuclear magnetic resonance spectroscopy (NMR), mass spectrometry (MS) and others. The market by application includes drug assessment, biomarker discovery, nutrigenomics, clinical toxicology and others. The market by geography is divided into five regions as North America, Europe, Asia Pacific, Latin America and Middle East and Africa.

The market overview section of the report demonstrates major market dynamics such as drivers, restraints, and opportunities that influence the current and future status of the industry. Porter’s five forces analysis provides information about the competitiveness of the industry. Moreover, the market attractiveness and competitive landscape provided in the market overview gives information about the lucrative markets for investment and major players in this market, respectively. The report concludes with the company profiles section, which includes key information about major players in the market such as financial overview, business strategies, and recent developments.

Major players in this market are Thermo Fisher Scientific, Inc. (U.S.), Agilent Technologies, Inc.(U.S.), Biocrates Life Sciences AG (Austria), Shimadzu Corporation (Japan), Waters Corporation (U.S.), Human Metabolome Technologies, Inc.(Japan), LECO Corporation (U.S.), Metabolon, Inc. (U.S.), Bio-Rad Laboratories, Inc.(U.S.), and Bruker Corporation (U.S.)

Global Metabolomics market has been segmented as follows:

Global Metabolomics Market, By Technique

Introduction

Separation Techniques

Detection Techniques

Global Metabolomics Market, By Application

Global Metabolomics Market, by Geography

Gas Chromatography (GC)

Capillary Electrophoresis (CE)‏

High Performance Liquid Chromatography (HPLC)‏

Ultra Performance Liquid Chromatography (UPLC)‏

Nuclear Magnetic Resonance Spectroscopy (NMR)‏

Mass Spectrometry (MS)

Introduction

Drug Assessment

Biomarker Discovery

Nutrigenomics

Clinical toxicology

Others

Introduction

North America

Europe

Asia Pacific

Latin America

Middle East and Africa

Rest of Middle East and Africa

United States

Canada

Germany

France

Rest of Europe

China

Japan

Rest of Asia Pacific

Brazil

Rest of Latin America

South Africa

Browse Full Report With TOC : http://www.mrrse.com/metabolomics-market

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